OmpK36-mediated Carbapenem resistance attenuates ST258 Klebsiella pneumoniae in vivo
Abstract Carbapenem-resistance in Klebsiella pneumoniae (KP) sequence type ST258 is mediated by carbapenemases (e.g.KPC-2) and loss or modification of the major non-selective porins OmpK35 and OmpK36.However, the mechanism underpinning OmpK36-mediated resistance and consequences of these changes on pathogenicity remain unknown.By solving the crysta